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I use despair at all times EXCEPT when I am AEing.
For instance, I've been farming for Xennu shards lately (blue 3dots) and I pull 3 mobs per pull and kill them all. In defensive, I can keep myself healed without despair on a 3-pull and the mobs die considerably faster with the DS up than with despair up, so I do that.
Most of the time, Despair, though. But the DS does have its moments.
I use the other symbol (the +damage one) if I were going to be killing mobs that cant really hurt me (say lowbie faction grinding).
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