I've alt-tabbed when the game starts getting 'choppy' after a couple hours of play.
Last night it was at 1,336,9xx bytes. I have 2GB RAM.
Eventually it causes a CTD. I flush when I feel there is a reason to, usually artifacts or black textures. I will try out some weekend day (when I play long time) by doing /flush every 30 mins or so and see if it prevents the inevitable (seemingly) CTD.
Smells like time to do at least Valgrind on it

OK... that would prob make it run so slow and require 40gb RAM to test on something this size but still ...

hope they find it soon.